The Red Devils signed the 30-year-old on loan from Shanghai Shenhua following Marcus Rashford’s serious back injury.
Ighalo has been added to the squad for the Round of 32 onwards, alongside new signings Bruno Fernandes and Nathan Bishop.
The news regarding the ex-Watford man’s inclusion will come as a boost for the Old Trafford giants and the player himself, with the Red Devils facing Club Brugge for a place in the last 16.
“He is a different type of striker and he is a proven goalscorer,” manager Ole Gunnar Solskjaer said of the ex-Nigeria international.
“He has a physical presence. Also, he gives us a chance to rest Mason and Anthony.
Solskjaer also has a full contingent of first-team stars to choose from, including Eric Bailly, Aaron Wan-Bissaka, Juan Mata and Anthony Martial.
United’s only loss in this season’s competition was their 2-1 defeat to Astana with Jesse Lingard scoring the lone goal.
Solskjaer’s team started the season in brutal fashion, defeating Chelsea 4-0 before recording two draws and one defeat in their following three games.
Before facing the Belgians, Manchester United must negotiate an away clash against Frank Lampard’s men on February 17.
Eric Bailly, Diogo Dalot, David De Gea, Bruno Fernandes, Fred, Odion Ighalo, Daniel James, Matej Kovar, Victor Lindelof, Anthony Martial, Juan Mata, Nemanja Matic, Sergio Romero.
Jesse Lingard, Scott McTominay, Andreas Pereira, Paul Pogba, Marcus Rashford, Luke Shaw, Axel Tuanzebe.